Biologically-Inspired Low-Light Vision Systems for Micro-Air Vehicle Applications

Various insect species such as the Megalopta genalis are able to visually stabilize and navigate at light levels in which individual photo-receptors may receive fewer than ten photons per second. They do so in cluttered forest environments with astonishing success while relying heavily on optic flow estimation. Such capabilities are nowhere near being met with current technology, in large part due to limitations of low-light vision systems. This dissertation presents a body of work that enhances the capabilities of visual sensing in photon-limited environments with an emphasis on low-light optic flow detection. We discuss the design and characterization of two optical sensors fabricated using complementary metal-oxide-semiconductor (CMOS) very large scale integration (VLSI) technology. The first is a frame-based, low-light, photon-counting camera module with which we demonstrate 1-D non-directional optic flow detection with fewer than 100 photons/pixel/frame. The second utilizes adaptive analog circuits to improve room-temperature short-wave infrared sensing capabilities. This work demonstrates a reduction in dark current of nearly two orders of magnitude and an improvement in signal-to-noise ratio of nearly 40dB when compared to similar, non-adaptive circuits. This dissertation also presents a novel simulation-based framework that enables benchmarking of optic flow algorithms in photon-limited environments. Using this framework we compare the performance of traditional optic flow processing algorithms to biologically-inspired algorithms thought to be used by flying insects such as the Megalopta genalis. This work serves to provide an understanding of what may be ultimately possible with optic flow sensors in low-light environments and informs the design of future low-light optic flow hardware

Symmetry-protected phases for measurement-based quantum computation

Ground states of spin lattices can serve as a resource for measurement-based quantum computation. Ideally, the ability to perform quantum gates via measurements on such states would be insensitive to small variations in the Hamiltonian. Here, we describe a class of symmetry-protected topological orders in one-dimensional systems, any one of which ensures the perfect operation of the identity gate. As a result, measurement-based quantum gates can be a robust property of an entire phase in a quantum spin lattice, when protected by an appropriate symmetry.Comment: 5 pages, 1 figure, comments welcome; v2 fixed minor typographic errors; v3 published versio

A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

Activation-induced cytidine deaminase (AID) is believed to initiate somatic hypermutation (SHM) by deamination of deoxycytidines to deoxyuridines within the immunoglobulin variable regions genes. The deaminated bases can subsequently be replicated over, processed by base excision repair or mismatch repair, leading to introduction of different types of point mutations (G/C transitions, G/C transversions and A/T mutations). It is evident that the base excision repair pathway is largely dependent on uracil-DNA glycosylase (UNG) through its uracil excision activity. It is not known, however, which endonuclease acts in the step immediately downstream of UNG, i.e. that cleaves at the abasic sites generated by the latter. Two candidates have been proposed, an apurinic/apyrimidinic endonuclease (APE) and the Mre11-Rad50-NBS1 complex. The latter is intriguing as this might explain how the mutagenic pathway is primed during SHM. We have investigated the latter possibility by studying the in vivo SHM pattern in B cells from ataxia-telangiectasia-like disorder (Mre11 deficient) and Nijmegen breakage syndrome (NBS1 deficient) patients. Our results show that, although the pattern of mutations in the variable heavy chain (VH) genes was altered in NBS1 deficient patients, with a significantly increased number of G (but not C) transversions occurring in the SHM and/or AID targeting hotspots, the general pattern of mutations in the VH genes in Mre11 deficient patients was only slightly altered, with an increased frequency of A to C transversions. The Mre11-Rad50-NBS1 complex is thus unlikely to be the major nuclease involved in cleavage of the abasic sites during SHM, whereas NBS1 might have a specific role in regulating the strand-biased repair during phase Ib mutagenesis

A 30 µW 30 fps 110 × 110 Pixels Vision Sensor Embedding Local Binary Patterns

We present a 110 × 110 pixel vision sensor that computes the Local Binary Patterns (LBPs) of an imaged scene with a power consumption of 30 μW at 30 fps. The LBP of a given pixel is a binary vector, encoding the direction and sign of image contrast with respect to its neighbors. Each LBP provides a visual description of an image's local structure that is widely used for texture and object recognition. In the sensor proposed here, each pixel detects its corresponding LBP with respect to its four neighboring pixels and saves this information into a digital map using 6 bits to encode each pixel. The operation is executed during the exposure time and requires 83 pW/pixel · frame to be computed. The chip is implemented in a 0.35 μm CMOS featuring 34 T square pixels with 26 μm pitch. We illustrate some examples of image description based on the LBPs output by the sensor